Mapping of non-central potentials under point canonical transformations

Motivated by the observation that all known exactly solvable shape invariant central potentials are inter-related via point canonical transformations, we develop an algebraic framework to show that a similar mapping procedure is also exist between a class of non-central potentials. As an illustrative example, we discuss the inter-relation between the generalized Coulomb and oscillator systems.Comment: 11 pages article in LaTEX (uses standard article.sty). Please check http://www1.gantep.edu.tr/~gonul for other studies of Nuclear Physics Group at University of Gaziante

Mining Integrated Sequential Patterns From Multiple Databases

Existing work on multiple databases (MDBs) sequential pattern mining cannot mine frequent sequences to answer exact and historical queries from MDBs having different table structures. This article proposes the transaction id frequent sequence pattern (TidFSeq) algorithm to handle the difficult problem of mining frequent sequences from diverse MDBs. The TidFSeq algorithm transforms candidate 1-sequences to get transaction subsequences where candidate 1-sequences occurred as (1-sequence, itssubsequenceidlist) tuple or (1-sequence, position id list). Subsequent frequent i-sequences are computed using the counts of the sequence ids in each candidate i-sequence position id list tuples. An extended version of the general sequential pattern (GSP)-like candidate generates and a frequency count approach is used for computing supports of itemset (I-step) and separate (S-step) sequences without repeated database scans but with transaction ids. Generated patterns answer complex queries from MDBs. The TidFSeq algorithm has a faster processing time than existing algorithms

Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.

OBJECTIVE: To compare fat distribution and associations between fat depots and cardiometabolic traits in South Asians and Europeans. METHODS: Five hundred and fourteen South Asians and 669 Europeans, aged 56-86. Questionnaires, record review, blood testing, and coronary artery calcification scores provided diabetes and clinical plus subclinical coronary heart disease (CHD) diagnoses. Abdominal visceral (VAT) and subcutaneous adipose tissue, thigh subcutaneous adipose tissue (TSAT), intermuscular and intramuscular thigh fat and thigh muscle were measured by CT. RESULTS: Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle. Associations between depots and disease were stronger in South Asians than Europeans. In multivariable analyses in South Asians, VAT was positively associated with diabetes and CHD, while TSAT and thigh muscle were protective for diabetes, and thigh muscle for CHD. Differences in VAT and thigh muscle only partially explained the excess diabetes and CHD in South Asians versus Europeans. Insulin resistance did not account for the effects of TSAT or thigh muscle. CONCLUSIONS: Greater VAT and TSAT and lesser thigh muscle in South Asians contributed to ethnic differences in cardiometabolic disease. Effects of TSAT and thigh muscle were independent of insulin resistance

Salmonella enterica biofilm-mediated dispersal by nitric oxide donors in association with cellulose nanocrystal hydrogels

Protected by extracellular polymers, microbes within biofilms are significantly more resistant to disinfectants. Current research has been instrumental in identifying nitric oxide donors and hydrogels as potential disinfectant additives. Nitric oxide (NO) donors are considered a very promising molecule as biofilm dispersal agents and hydrogels have recently attracted a lot of interest due to their biocompatible properties and ability to form stable thin films. When the NO donor MAHMA NONOate was dissolved in phosphate saline buffer, it was able to reduce the biomass of well-established biofilms up to 15% for at least 24 h of contact time. Encapsulation of MAHMA NONOate and molsidomine within a hydrogel composed of cellulose nanocrystals (CNC) has shown a synergistic effect in dispersing well-established biofilms: after 2 h of exposure, moderate but significant dispersion was measured. After 6 h of exposure, the number of cells transitioning from the biofilm to the planktonic state was up to 0.6 log higher when compared with non-treated biofilms. To further explore the transport processes of NO donors within hydrogels, we measured the nitric oxide flux from gels, at 25°C for a composite of 0.1 µM MAHMA NONOate–CNC. Nitric oxide diffuses up to 500 µm from the hydrogel surface, with flux decreasing according to Fick’s law. 60% of NO was released from the hydrogel composite during the first 23 min. These data suggest that the combined treatments with nitric oxide donor and hydrogels may allow for new sustainable cleaning strategies

Confinement and Viscoelastic effects on Chain Closure Dynamics

Chemical reactions inside cells are typically subject to the effects both of the cell's confining surfaces and of the viscoelastic behavior of its contents. In this paper, we show how the outcome of one particular reaction of relevance to cellular biochemistry - the diffusion-limited cyclization of long chain polymers - is influenced by such confinement and crowding effects. More specifically, starting from the Rouse model of polymer dynamics, and invoking the Wilemski-Fixman approximation, we determine the scaling relationship between the mean closure time t_{c} of a flexible chain (no excluded volume or hydrodynamic interactions) and the length N of its contour under the following separate conditions: (a) confinement of the chain to a sphere of radius D, and (b) modulation of its dynamics by colored Gaussian noise. Among other results, we find that in case (a) when D is much smaller than the size of the chain, t_{c}\simND^{2}, and that in case (b), t_{c}\simN^{2/(2-2H)}, H being a number between 1/2 and 1 that characterizes the decay of the noise correlations. H is not known \`a priori, but values of about 0.7 have been used in the successful characterization of protein conformational dynamics. At this value of H (selected for purposes of illustration), t_{c}\simN^3.4, the high scaling exponent reflecting the slow relaxation of the chain in a viscoelastic medium

Quantum phase space distributions in thermofield dynamics

It is shown that the the quantum phase space distributions corresponding to a density operator $\rho$ can be expressed, in thermofield dynamics, as overlaps between the state $\mid \rho >$ and "thermal" coherent states. The usefulness of this approach is brought out in the context of a master equation describing a nonlinear oscillator for which exact expressions for the quantum phase distributions for an arbitrary initial condition are derived.Comment: 17 pages, revtex, no figures. number of pages were incorrectly stated as 3 instead of 17. No other correction

The Schwinger SU(3) construction - I: Multiplicity problem and relation to induced representations

The Schwinger oscillator operator representation of SU(3) is analysed with particular reference to the problem of multiplicity of irreducible representations. It is shown that with the use of an $Sp(2,R)$ unitary representation commuting with the SU(3) representation, the infinity of occurrences of each SU(3) irreducible representation can be handled in complete detail. A natural `generating representation' for SU(3), containing each irreducible representation exactly once, is identified within a subspace of the Schwinger construction; and this is shown to be equivalent to an induced representation of SU(3).Comment: Latex, 25 page

Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells

BACKGROUND: Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene regulation and cell differentiation. Mutations in the human lamin A gene cause a spectrum of genetic diseases that affect specific tissues. Most available mouse models for laminopathies recapitulate disease symptoms for muscle diseases and progerias. However, loss of human lamin A/C also has highly deleterious effects on fetal development. Hence it is important to understand the impact of lamin A/C expression levels on embryonic differentiation pathways. METHODOLOGY AND PRINCIPAL FINDINGS: We have investigated the differentiation potential of mouse embryonic stem cells containing reduced levels of lamin A/C by detailed lineage analysis of embryoid bodies derived from these cells by culture. We initially carried out a targeted disruption of one allele of the mouse lamin A/C gene (). Undifferentiated wild-type and embryonic stem cells showed similar expression of pluripotency markers and cell cycle profiles. Upon spontaneous differentiation into embryoid bodies, markers for visceral endoderm such as α-fetoprotein were highly upregulated in haploinsufficient cells. However, neuronal markers such as β-III tubulin and nestin were downregulated. Furthermore, we observed a reduction in the commitment of cells into the myogenic lineage, but no discernible effects on cardiac, adipocyte or osteocyte lineages. In the next series of experiments, we derived embryonic stem cell clones expressing lamin A/C short hairpin RNA and examined their differentiation potential. These cells expressed pluripotency markers and, upon differentiation, the expression of lineage-specific markers was altered as observed with embryonic stem cells. CONCLUSIONS: We have observed significant effects on embryonic stem cell differentiation to visceral endoderm, neuronal and myogenic lineages upon depletion of lamin A/C. Hence our results implicate lamin A/C level as an important determinant of lineage-specific differentiation during embryonic development

Catalogue of herpetological types in the collection of the Bombay Natural History Society

The herpetological types of the Bombay Natural History Society, Bombay (now Mumbai), India, are listed, current to 11 October, 1998. The collection includes historical specimens collected by Major Frank Wall, from India, Myanmar (formerly Burma) and Iran, as well as those described more recently. The annotated list includes original citations, registration numbers, nature of type and present status of every taxa, with additional remarks where necessary. In all, 24 primary and secondary types are present, including 21 name-bearing taxa (including three Anura, three Sauria and 13 Serpentes)